@chubbyemu video of this case: • A Boy Rubbed 1 Tube Pain Relief Cream...
A Toddler Drank His Mom's Essential Oils: • A Boy Drank His Mom's Essential Oils....
Audiopodcast version of this video: https://anchor.fm/chubbyemu
Interview With a DNP Accident Survivor: • Conversation With A Rare Dinitropheno...
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Patient portrayed by Abram Cutshall
Mom and her toddler portrayed by Megan Pulley and her son
24Dinitrophenol is also an uncoupler of oxidative phosphorylation on top of salicylate
References:
Salicylate Toxicity from Exposure to a MethylsalicylateContaining Rubefacient. https://www.ncbi.nlm.nih.gov/pmc/arti...
Regional variation in percutaneous penetration of 14C cortisol in man. https://www.jidonline.org/article/S00...
Anatomy and physiology of chronic s pain https://www.ncbi.nlm.nih.gov/pmc/arti...
Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. https://pubmed.ncbi.nlm.nih.gov/10634...
ISPAD Clinical Practice Consensus Guidelines 2018: DKA and the hyperglycemic hyperosmolar state. https://pubmed.ncbi.nlm.nih.gov/29900...
Salicylates. Goldfrank, Lewis R, and Neal Flomenbaum. Goldfrank's Toxicologic Emergencies. New York: McGrawHill, 2006.
Unconscious Uncoupling – Managing pH in Salicylate. Tox and Hound. https://toxandhound.com/toxhound/phin...
Counterproductive effects of sodium bicarbonate in DKA. https://pubmed.ncbi.nlm.nih.gov/8550770/
AntiInflammatory Drugs in Patients with Ischemic Heart Disease. Journal of Clinical Medicine 10(13):2835
Risk Factors for Cerebral Edema in Children with Diabetic Ketoacidosis. N Engl J Med 2001; 344:264269. Risk Factors for Cerebral Edema in Children with Diabetic Ketoacidosis
Role of the mitochondrial permeability transition in salicylate toxicity to cultured rat hepatocytes: implications for the pathogenesis of Reye's syndrome. Toxicol Appl Pharmacol . 1997 Dec;147(2):43141. https://pubmed.ncbi.nlm.nih.gov/9439738/