The Cardinals rolled over Pitt, 379, in their final home game of the season. Louisville outgained Pitt 308124 in the first half and led 270 at halftime. In his final game in front of the Louisville crowd, quarterback Tyler Shough passed for 293 yards and two touchdowns on 1728 passing. Isaac Brown ran for 93 yards and two touchdowns on 13 carries. Defensive lineman Ashton Gillotte had two sacks and three tackles for loss in the game.

00:00:00 1st Quarter
00:06:14 2nd Quarter
00:13:25 3rd Quarter
00:18:20 4th Quarter