There are at least 13,000 worlds under the influence of the Great Houses of the Landraad at the start of the Dune Series. Holtzman drive technology allows for instantaneous travel between the world the inhabited planets of the galaxy. After the reign of the GodEmperor the Great Scattering of mankind would send humans out in all directions, into the untraceable reaches of space. 15 centuries passed before anyone would return out of the scattering into the former Atreides Empire. Over the 5000 years of the Dune Saga human beings continued to diversify. Some groups isolated themselves till the point where they were almost inhuman, but not quite. But even with human kinds exploration of deep space, there appears to be no concrete evidence of Alien Life.

The Dune Encyclopedia mentions the Legend of Ampoliros. This was during the time before the guild. This legend was spoken of on many worlds including Arrakis, Ix, Geidi Prime, and Ecaz, the legend speaks of the “Starsearcher '' a class 3 starship that continued to take on grander proportions until becoming a class 9 ship. According to the legend, in the year 480 BG the crew set off on a long journey towards the Niushe system. Partway through their journey, they came across an abandoned cargo vessel floating in space.

The crew supposedly went insane, they had been fully convinced that they and the rest of humanity were under attack by an unseen enemy. The Crew made the decision to fly into space in search of these unseen alien attackers until they eventually ran out of stores

The people of the Dune universe seem to have considered the idea of alien life. According to the great convention, the universal truce of mankind held in place by the Alliance of the Royal House, The Guild, and The Landsraad, the use of Atomic weapons is preserved for only Non Human Threats. The use of atomics against human s was grounds for immediate planetary obliteration. So it seems that the threat of Aliens conflict was at least somewhat thought of.


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